Peptide ligands of the urokinase receptor
US6794358B1 · kind B1 · utility
0Cited by
2References
4Claims
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Assignee
Inventors
Key dates
| Filing date | Sep 23, 1998 |
| Grant date | Sep 21, 2004 |
| Priority date | — |
| Expiry date | Sep 23, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel peptides that are capable of binding to uPAR and inhibiting the binding of an integrin and vitronectin are described. Also provided are nucleic acid sequences encoding the novel peptides. Methods for screening for small molecules, other peptides, or peptoids that mimic the antagonistic function of the peptides of the invention are described. The invention has applications in design of therapeutics for treating disorders characterized by upregulation of uPA and uPAR, and cancer and chronic inflammation, cell migration or uPAR: integrin binding interactions, and diagnostical applications to such disorders.
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