Methods and compositions for enhancing diffusion of therapeutic agents through tissue
US6794376B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 12, 2001 |
| Grant date | Sep 21, 2004 |
| Priority date | — |
| Expiry date | Mar 25, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/0008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods and compositions for enhancing the diffusion of therapeutic agents through mammalian tissue. In one embodiment, invention provides methods and compositions useful for enhancing the diffusion of gene therapy vectors through a mammalian tissue of interest. The method comprises delivering the therapeutic agent and a permeabilizer to the tissue of interest. The method may further comprise inducing hyperthermia in the tissue. In one embodiment, a composition in accordance with the present invention comprises a gene therapy vector containing a polynucleotide and a tissue permeabilizer. A method of destroying tissue is also provided. In one embodiment of this aspect of the invention, the method includes delivering a high concentration of tissue permeabilizer to the tissue and may also include inducing hyperthermia in the tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.