&bgr;-amino acid compounds as integrin antagonists

US6794386B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Markus Albers · Leverkusen, DE
• Thomas Lehmann · Langenselbold, DE
• Thomas Rölle · Leverkusen, DE
• Gerhard Müller · Krefeld, DE
• Gerhard Hessler · Hofheim, DE
• Masaomi Tajimi · Ebeye, US
• Karl Ziegelbauer · Wuppertal, DE
• Hiromi Okigami · Kyoto, JP
• Haruki Hasegawa · Ann Arbor, US

Key dates

• Filing date: Nov 19, 2002
• Grant date: Sep 21, 2004
• Expiry date: Feb 8, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of the general formula (I), wherein R1 together with the C atom to which it is attached, and R2 together with the N atom to which it is attached, form a piperidinyl ring; X represents a bond, oxygen or —NR12—; and Y represents oxygen; pharmaceutical compositions containing such a compound, as well as the use of such a compound for the production of pharmaceutical compositions, and for the treatment of inflammatory, auto-immune and immune diseases.