Drechsleranol derivatives, processes for their preparation and their use

US6794408B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Claudia Eder · Hofheim, DE
• Michael Kurz · Neustadt, DE
• Luigi Toti · Hochheim, DE

Key dates

• Filing date: Jan 27, 2003
• Grant date: Sep 21, 2004
• Expiry date: Jan 27, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/645
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides novel drechsleranol compounds of formula (I) which are formed by the microorganism Drechslera australlensis, ST 003360, DSM 14093, or a fungus ST 004112, DSM 14524, during fermentation. A process for their preparation, pharmaceutical compositions containing said drechsleranols their use for the treatment and/or prophylaxis of degenerative neuropathies, such as, Alzheimeu's disease, or psychiatric disorders, such as depression, sleep disturbance or seasonal affective disorder, and their use as chelating agents or antioxidants are also disclosed and claimed.