Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
US6794510B2 · kind B2 · utility
10Cited by
6References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 8, 2002 |
| Grant date | Sep 21, 2004 |
| Priority date | — |
| Expiry date | Aug 8, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C235/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto. The compounds prepared by the present processes may be useful, for example, as antagonists to the mu, kappa and delta opioid receptors, and thereby may be useful in the treatment of gastrointestinal motility disorders, and in preventing peripheral opiate induced side effects. The present processes may offer improved yields, purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.