Crystallographic structure of the androgen receptor ligand binding domain

US6795776B1 · kind B1 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Roberto Weinmann · Princeton, US
• Howard M. Einspahr · Lawrenceville, US
• Stanley Krystek · Ringoes, US
• John S. Sack · Lawrenceville, US
• Mark E. Salvati · Lawrenceville, US
• John S. Tokarski · Princeton, US
• Ricardo Attar · Lawrenceville, US
• Chihuei Wang · Plainsboro, US

Key dates

• Filing date: Oct 13, 2000
• Grant date: Sep 21, 2004
• Expiry date: Jun 16, 2021

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/723
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The first crystal structure of the androgen receptor ligand binding domain has been determined to 2.0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonists and selective androgen receptors modulators (SARMs) of the androgen receptor.