Inhibitors of cytosolic phospholipase A2

US6797708B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• John C. McKew · Ames, US
• Steven Y. Tam · Wellesley, US
• Katherine Lin Lee · Newton, US
• Lihren Chen · Cambridge, US
• Paresh Thakker · Boston, US
• Fuk-Wah Sum · Pomona, US
• Mark Behnke · Somerville, US
• Baihua Hu · Audubon, US
• James D. Clark · Acton, US

Key dates

• Filing date: Nov 22, 2002
• Grant date: Sep 28, 2004
• Expiry date: Jan 2, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.