Succinate compounds, compositions and methods of use and preparation
US6797820B2 · kind B2 · utility
14Cited by
74References
48Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 13, 2000 |
| Grant date | Sep 28, 2004 |
| Priority date | — |
| Expiry date | Jan 29, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.