Method of monitoring a biological system by labeling with an apo metal binding protein

US6800437B1 · kind B1 · utility

Assignee

• Tibotec BVBA · BE

Inventors

• Inge Dierynck · Berchem, BE
• Christiaan Hubert Simon Roelant · Leuven, BE
• Rudi Pauwels · Champéry, CH
• Koenraad Lodewijk August Van Acker · Temse, BE
• Jan Octaaf De Kerpel · Lede, BE

Key dates

• Filing date: Aug 4, 2000
• Grant date: Oct 5, 2004
• Expiry date: May 10, 2021

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/583
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention is directed to reporter molecules and tags that may be used to monitor a target substance in a biological system. More particularly, the present invention relates to the use of an apo metal binding protein as a reporter molecule or tag. An apo metal binding protein may be bound to a protein or tissue or introduced into a cell. The invention also relates to methods of utilizing the apo metal binding protein for detecting a cell expressing a protein of interest, localizing a protein in a cell, and designing a therapeutic agent for treating a disease or infection.