Modified forms of hepatitis C NS3 protease for facilitating inhibitor screening and structural studies of protease:inhibitor complexes
US6800456B2 · kind B2 · utility
5Cited by
6References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 27, 2001 |
| Grant date | Oct 5, 2004 |
| Priority date | — |
| Expiry date | Aug 20, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to modified Hepatitis C NS3 proteases and modified Hepatitis C NS4a-NS3 fusion proteases. These proteins are highly soluble and are useful for NMR spectroscopy, X-ray crystallography, and inhibitor screening. DNA constructs are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.