Modulators of Rho C activity

US6800634B2 · kind B2 · utility

Assignee

• Iconix Pharmaceuticals, Inc. · US

Inventors

• Dongxu Sun · Cupertino, US
• Edward Perkins · Savannah, US
• Stuart Tugendreich · Mountain View, US

Key dates

• Filing date: Nov 19, 2002
• Grant date: Oct 5, 2004
• Expiry date: Nov 19, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula 1 modulate the activity of Rho C: wherein R1 is H, OH, or lower alkyl;R2, R3, R4, R5, and R6 are each independently H, halo, lower alkyl, OH, lower alkoxy, NH2, lower alkylamino, di(lower alkyl)amino, SH, lower alkylthio, NO2, or two residues together form a heterocyclic ring;R7, R8, R9, and R10 are each independently H, lower alkyl, OH, NH2, aryl, or aralkyl, where aryl and aralkyl are substituted with 0-3 moieties selected from the group consisting of halo, OH, NH2, lower alkyl, lower alkoxy, SH, lower alkylthio, and lower alkylamino;R11, R12, R13, R14, R15, and R16 are each independently H, halo, lower alkyl, OH, lower alkoxy, or NO2;or a pharmaceutically acceptable salt thereof.