Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation

US6800658B2 · kind B2 · utility

Assignees

• Children's Medical Center Corporation · US
• President and Fellows of Harvard College · US
• NuChem Pharmaceuticals Inc. · CA

Inventors

• Carlo Brugnara · Newton, US
• Jose Halperin · Brookline, US
• Rudolf Fluckiger · Brookline, US
• Emile Bellott · Beverly, US
• Richard John Lombardy · Littleton, US
• John J. Clifford · Arlington, US
• Ying-Duo Gao · Murfreesboro, US
• Reem M. Haidar · Woburn, US
• Eugene Kelleher · Somerville, US
• Adel Moussa · Burlington, US
• Yesh P. Sachdeva · Concord, US
• Minghua Sun · Libertyville, US
• Heather N. Taft · Littleton, US

Key dates

• Filing date: Jan 10, 2002
• Grant date: Oct 5, 2004
• Expiry date: Jan 10, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.