Preparation of desflurane
US6800786B1 · kind B1 · utility
9Cited by
8References
5Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 21, 2003 |
| Grant date | Oct 5, 2004 |
| Priority date | — |
| Expiry date | Aug 21, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C41/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided is a method for the preparation of desflurane wherein isoflurane is reacted with 0.7-1.2 mol. % of antimony pentachloride and 1.3-2.2 molar equivalents of hydrogen fluoride. Typically, the method is conducted by addition of hydrogen fluoride to a mixture of isoflurane and antimony pentachloride. After the addition of hydrogen fluoride is completed, the reaction is preferably maintained at temperatures of about 9-18° C. for about 6 to 7 hours, before being quenched.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.