Method of delivering antigens for vaccination with a live vector
US6803231B1 · kind B1 · utility
0Cited by
3References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 21, 1999 |
| Grant date | Oct 12, 2004 |
| Priority date | — |
| Expiry date | Sep 21, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/523
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a mutant C. fetus strain in which one or more sapA homologs are altered by an inserted DNA cassette so that the encoded S-layer proteins represent a chimera between the native S-layer proteins and a heterologous peptide encoded by the inserted cassette. Preferably, the heterologous peptide is an immunogen of a pathogen and the mutant strain can be used to immunize a host to develop mucosal and systemic immune responses to such immunogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.