Method of regulating glucose metabolism, and reagents related thereto

US6803357B1 · kind B1 · utility

Assignees

• New England Medical Center Hospitals. Inc. · US
• Trustees of Tufts College · US
• 1149336 Ontario, Inc. · CA

Inventors

• William Bachovchin · Melrose, US
• Andrew G. Plaut · Lexington, US
• Daniel J. Drucker · Toronto, CA

Key dates

• Filing date: Jan 5, 2001
• Grant date: Oct 12, 2004
• Expiry date: Jan 5, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for modification and regulation of GLP 1 metabolism, glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia, obesity, hyperlipidemia, hyperlipoproteinemia (such as chylomicrons, VLDL and LDL), and to regulate body fat and more generally lipid stores, and, more generally, for the improvement of metabolism disorders, especially those associated with diabetes, obesity and/or atherosclerosis. The compositions described herein are high-affinity boronyl and non-boronyl peptidomimetic inhibitors of DPIV.