Compounds and methods for the treatment of neoplastic disease
US6803369B1 · kind B1 · utility
7Cited by
5References
3Claims
0Family size
Assignees
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Key dates
| Filing date | Jul 25, 2001 |
| Grant date | Oct 12, 2004 |
| Priority date | — |
| Expiry date | Jul 25, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/497
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with which the enzyme is in complex. Pharmaceutical compositions containing such compounds may be used to treat neoplasias or to inhibit the growth of certain cancer cells. Screening methods can be employed to identify other compounds for these uses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.