Methods of modulating immune coagulation
US6805863B2 · kind B2 · utility
1Cited by
1References
3Claims
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Key dates
| Filing date | Jul 12, 2001 |
| Grant date | Oct 19, 2004 |
| Priority date | — |
| Expiry date | Aug 24, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/245
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for mediating immune coagulation using novel antibodies and compounds are described. A protein Fgl2 having direct prothrombinase activity has been identified. Inhibitors of Fgl2 are useful in preventing and treating diseases which require a reduction in immune coagulation including bacterial and viral infections, allograft and xenograft rejection, glomerulonephritis, cancer, a number of gastrointestinal diseases and fetal loss.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.