Patent · US Expired

Non-endogenous, constitutively activated known G protein-coupled receptors

US6806054B2 · kind B2 · utility

4Cited by

4References

3Claims

0Family size

Assignee

Arena Pharmaceuticals, Inc. · US

Inventors

Karin Lehmann-Bruinsma · San Diego, US
Chen Liaw · San Diego, US
I-Lin Lin · San Diego, US

Key dates

Filing date	Apr 5, 2001
Grant date	Oct 19, 2004
Priority date	—
Expiry date	Jul 30, 2021

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.