Screening assays using intramitochondrial calcium
US6808873B2 · kind B2 · utility
82Cited by
5References
71Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 16, 2001 |
| Grant date | Oct 26, 2004 |
| Priority date | — |
| Expiry date | Jan 16, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5079
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect agents that bind to a mitochondrial calcium uniporter and may also detect inhibitors or uncouplers of mitochondrial respiration. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.