Method for determining susceptibility to heart disease by screening polymorphisms in the vitamin D receptor gene
US6808881B1 · kind B1 · utility
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4Claims
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Key dates
| Filing date | May 30, 2001 |
| Grant date | Oct 26, 2004 |
| Priority date | — |
| Expiry date | May 30, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/172
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to prognostic method and means for determining susceptibility to heart disease in a subject by screening for polymorphisms in the Vitamin D receptor gene. In particular, the present invention provides a method for determining susceptibility to heart disease, the method comprising analysing the genetic material of a subject to determine which of the B/b, A/a or T/t alleles of the restriction enzyme sites BsmI, ApaI and TaqI respectively are present. Specific combinations of alleles represent a haplotype which is associated with susceptibility to heart disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.