Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections

US6809083B1 · kind B1 · utility

Inventors

• Richard A. Mueller · Glencoe, US
• Martin Bryant · Carlisle, US
• Richard A. Partis · Evanston, US
• Gary S. Jacob · New York, US
• Timothy M. Block · Doylestown, US
• Raymond A. Dwek · Abingdon, GB

Key dates

• Filing date: Feb 12, 1999
• Grant date: Oct 26, 2004
• Expiry date: Feb 12, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.