Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase

US6811998B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Mitali Ghoshal · Noblesville, US
• Gerald Sigler · Carmel, US
• Raymond Hui · Indianapolis, US
• Ronald Charles Hawley · Oakland, US
• Eva Hoess · Starnberg, DE
• Erasmus Huber · Garching bei München, DE
• John W. Patterson · Maple Valley, US
• Salvatore J. Salamone · Stockton, US
• Allan Dorn · Carmel, US

Key dates

• Filing date: Jan 14, 2003
• Grant date: Nov 2, 2004
• Expiry date: Mar 9, 2023

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/904
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide.The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.