Heterocycle substituted purine derivatives as potent antiproliferative agents
US6812232B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 6, 2002 |
| Grant date | Nov 2, 2004 |
| Priority date | — |
| Expiry date | Sep 19, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The compounds of the present invention are 2,6,9-trisubstituted purine derivatives which are inhibitors of cyclin/cdk complexes. The compounds of the current invention also are potent inhibitors of human cellular proliferation. As such, the compounds of the present invention constitute pharmaceutical compositions with a pharmaceutically acceptable carrier. Such compounds are useful in treating a disorder mediated by elevated levels of cell proliferation in a mammal compared to a healthy mammal by administering to such mammal an effective amount of the compound. Examples of the compounds of the present invention are represented by the following chemical structures: wherein:V=NH;O;S; orCH2;R7 is a heterocycle selected from the group consisting of:thiophene;furan;pyrrole;thiazole;pyrazole;imidazole;isoxazole;isothiazole; and1,3,4-thiadiazole;and Y, A, R1, R2, R3, R4, and n1 are defined herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.