Methods of synthesizing acylanilides including bicalutamide and derivatives thereof
US6812362B2 · kind B2 · utility
2Cited by
8References
18Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 10, 2002 |
| Grant date | Nov 2, 2004 |
| Priority date | — |
| Expiry date | Oct 10, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C315/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods of synthesizing an acylanilide include contacting a compound having the structure of Formula I: with a compound having the structure of Formula II: under conditions sufficient to provide a compound having the structure of Formula III: and treating the compound of Formula III under conditions sufficient to provide an acylanilide. The compound of Formula III may be addition reacted with a compound having the structure of Formula IV:R5—X1—R6—R7   Formula IV under conditions sufficient to provide an acylanilide having the structure of Formula V:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.