Acetaldehyde and malondialdehyde protein adducts as markers for alcohol liver disease
US6814951B1 · kind B1 · utility
6Cited by
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3Claims
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Key dates
| Filing date | May 25, 1999 |
| Grant date | Nov 9, 2004 |
| Priority date | — |
| Expiry date | May 25, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/18
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A novel protein adduct is disclosed which is associated with the presence of alcohol liver disease. The adduct is a hybrid product of malondialdehyde and acetaldehyde which act synergistically to bind hepatic proteins. The adduct is highly immunogenic and fluorescent. Methods of detection are also disclosed including monoclonal and polyclonal antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.