Patent · US Expired

HIV-1 gp120 V1/V2 domain epitopes capable of generating neutralizing antibodies

US6815201B2 · kind B2 · utility

72Cited by

2References

32Claims

0Family size

Assignee

The Public Health Research Institute Of the City of New York, Inc. · US

Inventor

Abraham Pinter · Brooklyn, US

Key dates

Filing date	Jan 2, 2002
Grant date	Nov 9, 2004
Priority date	—
Expiry date	Jan 2, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2740/16134
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention features a protein which includes a gp120 V1/V2 domain of an HIV-1 strain and not a gp120 V3 domain of an HIV-1 strain, which protein does not substantially bind CD4. The gp120 V1/V2 domain of the protein displays an epitope which is recognized by an antibody which neutralizes at least one HIV-1 primary isolate with a ND90 of less than 100 &mgr;g/ml.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.