Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor

US6815416B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Darrell H. Carney · Dickinson, US
• Roger S. Crowther · League City, US
• Janet Stiernberg · Paris, US
• John Bergmann · Galveston, US

Key dates

• Filing date: Jul 19, 2001
• Grant date: Nov 9, 2004
• Expiry date: Aug 6, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.