TGF-&agr; polypeptides, functional fragments and methods of use therefor
US6815418B2 · kind B2 · utility
5Cited by
23References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 17, 2001 |
| Grant date | Nov 9, 2004 |
| Priority date | — |
| Expiry date | Nov 2, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are TGF-&agr; polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.