EC-3, an inhibitor of &agr;4&bgr;1 and &agr;4&bgr;7 integrins
US6818617B1 · kind B1 · utility
33Cited by
2References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 7, 2000 |
| Grant date | Nov 16, 2004 |
| Priority date | — |
| Expiry date | Feb 7, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/856
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to the identification, purification, and characterization of a novel heterodimeric disintegrin, EC-3, from Echis carinatus viper venom. EC-3 inhibits &agr;4 integrins in an RGD-independent manner. The invention further relates to methods of using EC-3, or a biologically active fragment or derivative thereof, to inhibit the interaction between cells expressing &agr;4 integrins and cellular ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.