Patent · US Expired

Active hedgehog protein conjugate

US6818623B2 · kind B2 · utility

1Cited by

3References

14Claims

0Family size

Assignee

Curis, Inc. · US

Inventors

Angelika Esswein · Büttelborn, DE
Kurt Lang · Penzberg, DE
Petra Rueger · Penzberg, DE
Tilman Seytter · Gräfelfing, DE

Key dates

Filing date	Oct 21, 2002
Grant date	Nov 16, 2004
Priority date	—
Expiry date	Oct 25, 2022

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.