Biologically active materials

US6818630B1 · kind B1 · utility

Assignee

• M.L. Laboratories PLC · GB

Inventors

• Ruth Duncan · Cardiff, GB
• Dale Howard Hreczuk-Hirst · London, GB
• Lisa German · London, GB

Key dates

• Filing date: Jul 30, 2002
• Grant date: Nov 16, 2004
• Expiry date: Jul 30, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure concerns biologically active materials, particularly materials that comprise a biodegradeable polymer linked to a biologically active agent. The disclosure further concerns materials known as polymer-drug conjugates that typically contain a therapeutic agent, for instance a bioactive cytotoxic drug linked to a polymer backbone. The linkage typically is a convalent linkage. However, in some embodiments the disclosure concerns other polymer conjugates including those where the biologically active agent is an imaging agent, such as a tyrosinamide, a diagnostic agent, or a targeting agent, such as biotin.