Acylated piperidine derivatives as melanocortin-4 receptor agonists

US6818658B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Feroze Ujjainwalla · Hoboken, US
• Lin Chu · Scotch Plains, US
• Mark Goulet · Westfield, US
• Bonnie Louridas · Somerville, US
• Matthew J. Wyvratt · Mountainside, US
• Daniel Warner · Stoneham, US

Key dates

• Filing date: Feb 3, 2003
• Grant date: Nov 16, 2004
• Expiry date: Feb 3, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.