Compositions and methods for the therapy and diagnosis of prostate cancer

US6818751B1 · kind B1 · utility

Assignee

• CORIXA CORPORATION · US

Inventors

• Jiangchun Xu · Bellevue, US
• Davin C. Dillon · Issaquah, US
• Jennifer Mitcham · Redmond, US
• Susan Harlocker · Foster City, US
• Yuqiu Jiang · Kent, US
• Michael D. Kalos · Philadelphia, US
• Gary Fanger · Mill Creek, US
• Marc Retter · Carnation, US
• John Stolk · Bothell, US
• Craig Day · Seattle, US
• Thomas S. Vedvick · Federal Way, US
• Darrick Carter · Seattle, US
• Samuel X. Li · Redmond, US
• Aijun Wang · Davis, US
• Yasir Skeiky · Bellevue, US
• William T. Hepler · Seattle, US
• Robert A. Henderson · Seattle, US

Key dates

• Filing date: Aug 29, 2000
• Grant date: Nov 16, 2004
• Expiry date: Aug 29, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.