Human endothelin receptor
US6821743B2 · kind B2 · utility
1Cited by
4References
3Claims
0Family size
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Key dates
| Filing date | Aug 16, 2001 |
| Grant date | Nov 23, 2004 |
| Priority date | — |
| Expiry date | Aug 16, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/72
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
DNA encoding an endothelin receptor shown in SEQ ID NO: 1 or 2 in the Sequence Listing is isolated from cDNA which is prepared from poly(A)+RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin receptor is obtained by culturing this transformant. A receptor shown in SEQ ID NO: 1 is an ETA-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 2 is an ETB-receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.