Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells
US6821778B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 28, 1996 |
| Grant date | Nov 23, 2004 |
| Priority date | — |
| Expiry date | Feb 28, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/57
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to methods of using human dendritic cells to present antigens for the induction of antigen-specific T cell-mediated immune responses. In particular, it relates to the isolation of dendritic cells from human blood, exposing the cells to antigens, co-culturing the antigen-pulsed dendritic cells with &ggr;&dgr;-T cell receptor-positive-T cells (&ggr;&dgr;-TCR+ T cells) obtained from unprimed or weakly primed individuals for the stimulation of antigen-specific T cell proliferative and cytotoxic activities. The dendritic cell antigen presentation system described herein has a wide range of applications, including but not limited to, activation and expansion of large numbers of antigen-specific major histocompatibility complex-unrestricted T cells for use in adoptive cellular immunotherapy against infectious diseases and cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.