4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors

US6821963B2 · kind B2 · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Stephen Douglas Barrett · Hartland, US
• Alexander James Bridges · Saline, US
• Annette Marian Doherty · Ann Arbor, US
• David T. Dudley · Ann Arbor, US
• Alan R. Saltiel · Ann Arbor, US
• Haile Tecle · Ann Arbor, US

Key dates

• Filing date: Jun 4, 2002
• Grant date: Nov 23, 2004
• Expiry date: Jun 4, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.