Inhibitors of p38 kinase
US6821966B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 20, 2001 |
| Grant date | Nov 23, 2004 |
| Priority date | — |
| Expiry date | Nov 20, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to methods to inhibit p38-&agr; kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein<CUSTOM-CHARACTER FILE="US06821966-20041123-P00001.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00001"/> represents a single or double bond;B is —Wi—COXjY wherein Y is COR2 or an isostere thereof and R2 is hydrogen or a noninterfering substituent, each of W and X is a spacer of 2-6 å, and each of i and j is independently 0 or 1;each R3 is independently a noninterfering substituent, where n is 0-3;Z3 is NR7 or O; wherein R7 is H or a noninterfering substituent;one Z2 is CA or CR8A and the other is CR1, CR12, NR6 or N wherein each R1, R6 and R8 is independently hydrogen or noninterfering substituent; wherein A is: such that Z1 is CR5 or N wherein R5 is hydrogen or a noninterfering substituent;each of l and k is an integer from 0-2 wherein the sum of l and k is 0-3;Ar is an aryl group substituted with 0-5 noninterfering substituents, wherein two noninterfering substituents can form a fused ring;each R4 is independently a noninterfering substituent where m …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.