Polymerizable macromers and preparation thereof
US6822064B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 29, 2003 |
| Grant date | Nov 23, 2004 |
| Priority date | — |
| Expiry date | Oct 29, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F2/06
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
The present invention relates to a polymerizable macromers for applications in medicine and biotechnology and synthesis thereof. Macromers comprises polyvalent various carbohydrates including N-Acetyl Glucosamine(NAG) which bind more efficiently to lysozyme than NAG itself. Effective inhibition of lysozyme is possible even at very low ligand concentrations. The polymerizable macromer could be used for prevention and treatment of bacterial and viral infections. Moreover these macromers can be copolymerized with other comonomers to form stimuli sensitive polymers and used for the recovery of biomolecules. The methodology can be extended to other ligands such as sialic acid and used for preventing influenza and/or rotavirus infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.