Patent · US Expired

Truncated CRAF1 inhibits CD40 signaling

US6822070B2 · kind B2 · utility

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2Claims

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Inventors

David Baltimore · Pasadena, US
Genhong Cheng · Los Angeles, US
Zheng-Sheng Ye · New York, US
Seth Lederman · New York, US
Aileen Cleary · New York, US

Key dates

Filing date	Mar 10, 1997
Grant date	Nov 23, 2004
Priority date	—
Expiry date	Apr 10, 2017

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Overexpression of a CRAF1 (CD40 receptor-associated factor 1) gene truncated by 323 to about 414 amino acids at the amino inhibits CD40-mediated cell activation, and is used to treat conditions characterized by an unwanted level of CD40-mediated intracellular signaling.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.