Process for production of fluoroalkoxy-substituted benzamides and their intermediates
US6822114B1 · kind B1 · utility
7Cited by
9References
51Claims
0Family size
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Key dates
| Filing date | Oct 8, 2002 |
| Grant date | Nov 23, 2004 |
| Priority date | — |
| Expiry date | Jan 23, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Roflumilast and new key intermediates therefor are prepared by processes involving use of carbonylation technology. Good overall yields can be achieved using available starting materials. The starting material for the process can be catechol, an o-R1-phenol, an o-R1-p-X-phenol, or a 1-X-3-R1-4-R2-benzene, where R1, is a C1-6 alkoxy, C3-7 cycloalkoxy, C3-7 cycloalkylmethoxy, or benzyloxy group, or a C1-4 alkoxy group which is completely or partially substituted by fluorine; R2 is a C1-4 alkoxy group which is completely or partially substituted by fluorine; and X is Cl, Br, or I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.