NIK-knockout mice
US6822138B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 2000 |
| Grant date | Nov 23, 2004 |
| Priority date | — |
| Expiry date | Mar 3, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0337
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides transgenic non-human mammals and cells having one or more structurally and functionally disrupted NIK alleles. In addition, the present invention provides methods for making such transgenic mammals and cells, and methods for determining the effect of a compound on an animal or cell that lacks NIK function. The present invention also provides methods for identifying compounds useful in the inhibition of osteoclastogenesis in a mammal, for example to treat osteoporosis or other conditions. Also provided are methods of modulating the extent of osteoclastogenesis in a cell or a mammal using NIK modulators.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.