Diacylglycerol acyl transferase proteins
US6822141B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 15, 2002 |
| Grant date | Nov 23, 2004 |
| Priority date | — |
| Expiry date | May 13, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides diacylglycerol acyltransferase (DAGAT) proteins, wherein said proteins are active in the formation of triacylglycerol from fatty acyl and diacylglycerol substrates. In one aspect, Mortierella ramanniana DAGAT proteins have been isolated and have molecular weights of between approximately 36 and 37 kDa as measured by SDS-PAGE. The invention also provides novel DAGAT polynucleotide and polypeptide sequences and to methods of producing such polypeptides using recombinant techniques. In addition, methods are provided for using such sequences to alter triacylglycerol levels in plants and to treat diseases associated with altered DAGAT activity or expression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.