Adenovirus gene expression system
US6824770B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | May 24, 1996 |
| Grant date | Nov 30, 2004 |
| Priority date | — |
| Expiry date | May 24, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/44
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention is directed to an adenoviral vector comprising (a) at least one insertion site for cloning a heterologous gene, and, in an orientation opposite to the direction of transcription of the adenoviral region into which it is inserted, (b) a heterologous promoter positioned upstream from the insertion site, (c) a eukaryotic splice acceptor and splice donor site positioned between the promoter and the insertion site; and (c) a polyadenylation sequence positioned downstream of the insertion site. The invention also provides a host cell infected with such a vector, a method of producing a selected protein, and a method of delivering a heterologous gene to an animal heart.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.