Residual solvent extraction method and microparticles produced thereby
US6824822B2 · kind B2 · utility
28Cited by
38References
14Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 31, 2001 |
| Grant date | Nov 30, 2004 |
| Priority date | — |
| Expiry date | Oct 9, 2022 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/0877
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.