Patent · US Expired

Polypeptides having &bgr;-1,3-galactosyl transferase activity

US6825019B2 · kind B2 · utility

9Cited by
3References
7Claims
0Family size

Assignee

Inventors

Key dates

Filing dateNov 21, 2002
Grant dateNov 30, 2004
Priority date—
Expiry dateNov 21, 2022

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12P19/18
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an &agr;2,3- and an &agr;2,8-activity. A &bgr;1,4-GalNAc transferase and a &bgr;1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.