17&agr;-fluoroalkyl-11&bgr;-benzaldoxime steroids, process for their production, pharmaceutical preparations that contain these steroids as well as their use for the production of pharmaceutical agents

US6825182B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Sven Ring · Jena, DE
• Gerd Schubert · Jena, DE
• Ingo Tornus · Hennigsdorf, DE
• Guenter Kaufmann · Jena, DE
• Walter Elger · Berlin, DE
• Birgitt Schneider · Jena, DE

Key dates

• Filing date: May 5, 2003
• Grant date: Nov 30, 2004
• Expiry date: May 5, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J75/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of general formula I as well as their pharmaceutically compatible salts are described, in which R1 stands for hydrogen, C1- to C6-alkyl, COR4, COOR4, COSR4 or CONHR5, in which R4 is C1- to C6-alkyl or unsubstituted or substituted aryl and in which R5 is hydrogen, C1- to C6-alkyl or unsubstituted or substituted aryl, in which R2 also stands for hydrogen, C1- to C6-alkyl or C1- to C6-acyl, and R3 stands for a CnF2n+1 group, in which n=1, 2 or 3, or a CH2O(CH2)mCnF2n+1 group, in which m=0 or 1 and n=1, 2 or 3. In addition, a process for the production of the compounds with general formula I is indicated. The compounds can be used for the production of pharmaceutical agents.