Indole, azaindole and related heterocyclic amidopiperazine derivatives

US6825201B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Tao Wang · Farmington, US
• Owen Brendan Wallace · Zionsville, US
• Nicholas A. Meanwell · East Hampton, US
• Zhongxing Zhang · Wallingford, US
• John A. Bender · Middletown, US
• John F. Kadow · Wallingford, US
• Kap-Sun Yeung · Madison, US

Key dates

• Filing date: Apr 22, 2002
• Grant date: Nov 30, 2004
• Expiry date: Apr 22, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention comprises substituted indole, azaindole and related heterocyclic amidopiperazine derivatives of general Formula I wherein:Q is —may represent a bond;A is selected from the group consisting of C1-6alkoxy, C1-6alkyl, C3-7cycloalkyl, phenyl, and heteroaryl; wherein said heteroaryl may be monocyclic or bicyclic and may be comprised of three to eleven atoms selected from the group consisting of C, N, NR9, O, and S, and wherein each ring of said phenyl and heteroaryl is optionally substituted with one to five same or different substituents selected from the group consisting of R19-R23;T is U is NR7, O, or S;V is C(H)kR1, O or N(R7′)k; W is CR3 or NR10;X is CR4 or NR10;Y is CR5 or NR10;Z is CR6 or NR10;k is 0 or 1; and m, n, and p are each independently 0, 1, or 2 provided that the sum of m, n, and p must equal 1 or 2; compositions thereof and their use as antiviral agents, particularly for treating HIV infection.