Molecular pathogenicide mediated plant disease resistance

US6825325B1 · kind B1 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Rainer Fischer · Monschau, DE
• Stefan Schillberg · Aachen, DE
• Jörg Nähring · Aachen, DE
• Markus Sack · Aachen, DE
• Michael Monecke · Aachen, DE
• Yu-Cai Liao · Aachen, DE
• Holger Spiegel · Aachen, DE
• Sabine Zimmerman · Aachen, DE
• Neil Emans · Pretoria, ZA

Key dates

• Filing date: Oct 18, 1999
• Grant date: Nov 30, 2004
• Expiry date: Oct 18, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention is drawn to a fusion protein containing at least one binding domain that specifically recognizes an eptitope of a plant pathogen and at least one additional domain made from a protein or peptide sequence which is toxic to the pathogen or detrimental the replication, transmission or life cycle of the pathogen. The present invention is further drawn to a pathogenocide made from the binding domain, a cellular targeting sequence and/or membrane localization sequence that leads to membrane anchoring. The present invention is further drawn to nucleotide sequences encoding fusion proteins and pathogenocides and to vectors containing the nucleotide sequences; as well as methods of making the fusion proteins and pathogencides and methods of making pathogen resistant plants, plant cells, or plant tissues with the fusion proteins and pathogenocides.