Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

US6828297B2 · kind B2 · utility

Assignee

• Nobex Corporation · US

Inventors

• Nnochiri Ekwuribe · Cary, US
• Christopher H. Price · Chapel Hill, US
• Aslam M. Ansari · Rockville, US
• Balasingam Radhakrishnan · Chapel Hill, US
• Amy L. Odenbaugh · Morrisville, US

Key dates

• Filing date: Jun 4, 2001
• Grant date: Dec 7, 2004
• Expiry date: Mar 30, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P5/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.