Charged lipid compositions and methods for their use
US6828306B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 3, 2003 |
| Grant date | Dec 7, 2004 |
| Priority date | — |
| Expiry date | Mar 3, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P39/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a pharmaceutical composition comprising a synthetic or naturally occurring charged phospholipid, which is formulated into a dosage form for administration to a subject or which is administered as a food additive. Negatively charged phospholipid composition increase the net negative charge on intravascular lipoproteins, enhance the clearance of cholesterol and regulate the function of lipolytic enzymes, retard prothrombin formation and aid in the clearance of virus and bacterial particles. Negatively charged lipid compositions can therefore be administered to humans and animals for the treatment of hyperlipidemia and blood coagulation disorders and to reduce the levels of virus, bacteria, and endotoxins in the blood stream. Positively charged lipid compositions can be administered to delay lipoprotein clearance from the plasma compartment and give longer duration of activity for drugs which are associated with lipoproteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.